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PUBLICATIONS
SCIENTIFIQUES

Révolutionner le développement
de vaccins et de protéines thérapeutiques

Voici les études et les articles publiés à ce jour par les chercheurs de Medicago.

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9 août 2021 Vaccin
Durability and Cross-Reactivity of Immune Responses Induced by an AS03 Adjuvanted Plant-Based Recombinant Virus-Like Particle Vaccine for COVID-19
Auteurs: Philipe A.M. Gobeil, Stéphane Pillet, Iohann Boulay, Nathalie Charland, Aurélien Lorin, Matthew Cheng, Donald Vinh, Philippe Boutet, Robbert Van Der Most, François Roman, Maria de los Angeles Ceregido Perez, Marc-André D'Aoust, Nathalie Landry, Brian Ward
17 mai 2021 Vaccin
Interim Report of a Phase 2 Randomized Trial of a Plant-Produced Virus-Like Particle Vaccine for Covid-19 in Healthy Adults Aged 18-64 and Older Adults Aged 65 and Older
Auteurs: Philipe Gobeil, Stéphane Pillet, Annie Séguin, Iohann Boulay, Asif Mahmood, Donald C Vinh, Nathalie Charland, Philippe Boutet, François Roman, Robbert Van Der Most, Maria de los Angeles Ceregido Perez, Brian J Ward, Nathalie Landry
6 novembre 2020 Vaccin
Phase 1 trial of a Candidate Recombinant Virus-Like Particle Vaccine for Covid-19 Disease Produced in Plants
Auteurs: Brian J Ward, Philipe Gobeil, Annie Séguin, Judith Atkins, Iohann Boulay, Pierre-Yves Charbonneau, Manon Couture, Marc-André D'Aoust, Jiwanjeet Dhaliwall, Carolyn Finkle, Karen Hager, Asif Mahmood, Alexander Makarkov, Matthew Cheng, Stéphane Pillet, Patricia Schimke, Sylvie St-Martin, Sonia Trépanier, Nathalie Landry
13 octobre 2020 Vaccin
Lancet publication: First human efficacy study of a plant-derived influenza vaccine
Auteurs: Brian J Ward, Alexander Makarkov, Annie Séguin, Stéphane Pillet, Sonia Trépanier, Jiwanjeet Dhaliwall, Michael D Libman, Timo Vesikari, Nathalie Landry
4 novembre 2019 Vaccin
Prime-pull vaccination with a plant-derived virus-like particle influenza vaccine elicits a broad immune response and protects aged mice from death and frailty after challenge
Auteurs: Breanna Hodgins, Stephane Pillet, Nathalie Landry and Brian J. Ward
5 juin 2019 Vaccin
Immunogenicity and safety of a quadrivalent plant-derived virus-like particle influenza vaccine candidate—Two randomized Phase II clinical trials in 18 to 49 and 50 years old adults
Auteurs: Stéphane Pillet, Julie Couillard, Sonia Trépanier, Jean-François Poulin, Bader Yassine-Diab, Bruno Guy, Brian J. Ward, Nathalie Landry
15 mai 2019 Vaccin
Plant-derived virus-like particle vaccines drive cross-presentation of influenza A hemagglutinin peptides by human monocyte-derived macrophages
Auteurs: Makarkov, Makan Golizeh, Elizabeth Ruiz-Lancheros, Angelica A. Gopal, Ian N. Costas-Cancelas, Sabrina Chierzi, Stephane Pillet, Nathalie Charland, Nathalie Landry, Isabelle Rouiller, Paul W. Wiseman, Momar Ndao, and Brian J. Ward
31 octobre 2018 Vaccin
Characterization of the innate stimulatory capacity of plant-derived virus-like particles bearing influenza hemagglutinin
Auteurs: So-Yoon Wona, Kristin Hunt, Hannah Guak, Benedeta Hasaj, Nathalie Charland, Nathalie Landry, Brian J. WardConnie M. Krawczyk
31 octobre 2018 Vaccin
Investigation of an Adventitious Agent Test False Positive Signal in a Plant-Derived Influenza Vaccine
Auteurs: Todd L. Talarico, Michael Murphy, Raymond Nims, Dan Hastings, Jeri Ann Boose, and Dave Dumers
12 septembre 2018 Vaccin
L'adjuvant GLA-AF améliore les réponses du vaccin intradermique chez l'humain
Auteurs: Darrick Carter, Neal van Hoeven, Susan Baldwin, Yotam Levin, Efrat Kochba, Al Magill, Nathalie Charland, Nathalie Landry, Khin Nu, Aude Frevol, Jill Ashman, Zachary K. Sagawa, Anna Marie Beckmann, Steven G. Reed
24 avril 2018 Vaccin
Assessing the benefits of early pandemic influenza vaccine availability: a case study for Ontario, Canada
Auteurs: David Champredon, Marek Laskowski, Nathalie Charland & Seyed M. Moghadas
23 février 2018 Vaccin
Morphological characterization of a plant-made virus-like particle vaccine bearing influenza virus hemagglutinins by electron microscopy.
Auteurs: Lindsay BJ, Bonar MM, Costas-Cancelas IN, Hunt K, Makarkov AI, Chierzi S, Krawczyk CM, Landry N, Ward BJ, Rouiller I.
16 janvier 2018 Vaccins et Immunothérapies
The establishment of surrogates and correlates of protection: Useful tools for the licensure of effective influenza vaccines?
Auteurs: Ward BJ, Pillet S, Charland N, Trepanier S, Couillard J, Landry N.
11 octobre 2017 Vaccin
A single intramuscular dose of a plant-made virus-like-particle vaccine elicits a balanced humoral and cellular response and protects young and aged mice from influenza H1N1 challenge 4despite a modest/absent humoral response
Auteurs: Breanna Hodgins, Karen K Yam, Kaitlin Winter, Stephane Pillet, Nathalie Landry and Brian J. Ward
2 juillet 2017 Vaccin
Plant-made virus-like particles bearing influenza hemagglutinin (HA) recapitulate early interactions of native influenza virions with human monocytes/macrophages.
Auteurs: Makarkov AI, Chierzi S, Pillet S, Murai KK, Landry N, Ward BJ
2 mai 2017 Vaccins et Immunothérapies
Plant-made virus-like particle vaccines bearing the hemagglutinin of either seasonal (H1) or avian (H5) influenza have distinct patterns of interaction with human immune cells in vitro.
Auteurs: Hendin HE, Pillet S, Lara AN, Wu CY, Charland N, Landry N, Ward BJ.
16 octobre 2017
Plant-made virus-like particle vaccines bearing the hemagglutinin of either seasonal (H1) or avian (H5) influenza have distinct patterns of interaction with human immune cells in vitro
Auteurs: Hilary E. Hendin, Stéphane Pillet, Amanda N. Lara, Cheng-Ying Wua, Nathalie Charland, Nathalie Landry, Brian J. Ward
24 juillet 2016 Vaccin
Cell wall biochemical alterations during Agrobacterium-mediated expression of haemagglutinin-based influenza virus-like vaccine particles in tobacco
Auteurs: Franccois Le Mauff, Corinne Loutelier-Bourhis, Muriel Bardor, Caroline Berard, Alain Doucet, Marc-André D'Aoust, Louis-Philippe Vezina, Azeddine Driouich, Manon M.-J. Couture and Patrice Lerouge
2 octobre 2015 Vaccin
Plant-derived H7 VLP vaccine elicits protective immune response against H7N9 influenza virus in mice and ferrets
Auteurs: S. Pillet, T. Racine, C. Nfond, T.Z. Di Lenardob, S. Babiukd, B.J. Ward, G.P. Kobingerc, N. Landry
2 juin 2015 Vaccin
Generation and characterization of a trackable plant-made influenza H5 virus-like particle (VLP) containing enhanced green fluorescent protein (eGFP)
Auteurs: Katie R. Young, Guillaume Arthus-Cartier, Karen K. Yam, Pierre-Olivier Lavoie, Nathalie Landry, Marc-André D'Aoust, Louis-Philippe Vézina, Manon M.-J. Couture, and Brian J. Ward
21 avril 2015
Modulating secretory pathway pH by proton channel co-expression can increase recombinant protein stability in plants
Auteurs: Philippe V. Jutras, Marc-André D'Aoust, Manon M.-J. Couture, Louis-Philippe Vézina, Marie-Claire Goulet, Dominique Michaud, Frank Sainsbury
19 septembre 2014
Human antibody response to N-glycans present on plant-madeinfluenza virus-like particle (VLP) vaccines
Auteurs: Brian J. Ward, Nathalie Landry, Sonia Trépanier, Geneviève Mercier,Michèle Dargis, Manon Couture, Marc-André D'Aoust, Louis-P. Vézinab
14 août 2014
Influenza virus-like particle vaccines made in Nicotiana benthamiana elicit durable, poly-functional and cross-reactive T cell responses to influenza HA antigens
Auteurs: Nathalie Landry, Stéphane Pillet, David Favre, Jean-François Poulin, Sonia Trépanier, Bader Yassine-Diab, Brian J. Ward